Functional activity All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm. Morphology [Histology] Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes. Primary malignant neoplasms overlapping site boundaries A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned. Malignant neoplasm of ectopic tissue Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Malignant neoplasms of mesothelial and soft tissue (C45-C49)
Mesothelioma of peritoneum Mesothelioma of cul-de-sac Mesothelioma of mesentery Mesothelioma of mesocolon Mesothelioma of omentum Mesothelioma of peritoneum (parietal) (pelvic)
Excludes 1:
other malignant neoplasm of soft tissue of peritoneum (C48.-)
Kaposi's sarcoma of soft tissue Kaposi's sarcoma of blood vessel Kaposi's sarcoma of connective tissue Kaposi's sarcoma of fascia Kaposi's sarcoma of ligament Kaposi's sarcoma of lymphatic(s) NEC Kaposi's sarcoma of muscle
Excludes 2:
Kaposi's sarcoma of lymph glands and nodes (C46.3)
Malignant neoplasm of peripheral nerves and autonomic nervous system, unspecified Malignant neoplasm of unspecified site of peripheral nerves and autonomic nervous system
C48
Malignant neoplasm of retroperitoneum and peritoneum[+]
Excludes 1:
Kaposi's sarcoma of connective tissue (C46.1) mesothelioma (C45.-)
Malignant neoplasm of specified parts of peritoneum Malignant neoplasm of cul-de-sac Malignant neoplasm of mesentery Malignant neoplasm of mesocolon Malignant neoplasm of omentum Malignant neoplasm of parietal peritoneum Malignant neoplasm of pelvic peritoneum
Malignant neoplasm of overlapping sites of retroperitoneum and peritoneum
C49
Malignant neoplasm of other connective and soft tissue[+]
Includes:
malignant neoplasm of blood vessel malignant neoplasm of bursa malignant neoplasm of cartilage malignant neoplasm of fascia malignant neoplasm of fat malignant neoplasm of ligament, except uterine malignant neoplasm of lymphatic vessel malignant neoplasm of muscle malignant neoplasm of synovia malignant neoplasm of tendon (sheath)
Excludes 1:
malignant neoplasm of cartilage (of): articular (C40-C41) larynx (C32.3) nose (C30.0) malignant neoplasm of connective tissue of breast (C50.-)
Excludes 2:
Kaposi's sarcoma of soft tissue (C46.1) malignant neoplasm of heart (C38.0) malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-) malignant neoplasm of peritoneum (C48.2) malignant neoplasm of retroperitoneum (C48.0) malignant neoplasm of uterine ligament (C57.3) mesothelioma (C45.-)
Malignant neoplasm of connective and soft tissue of head, face and neck Malignant neoplasm of connective tissue of ear Malignant neoplasm of connective tissue of eyelid
Excludes 1:
connective tissue of orbit (C69.6-)
C49.1
Malignant neoplasm of connective and soft tissue of upper limb, including shoulder[+]
Malignant neoplasm of connective and soft tissue of thorax Malignant neoplasm of axilla Malignant neoplasm of diaphragm Malignant neoplasm of great vessels
Excludes 1:
malignant neoplasm of breast (C50.-) malignant neoplasm of heart (C38.0) malignant neoplasm of mediastinum (C38.1-C38.3) malignant neoplasm of thymus (C37)
Malignant neoplasm of overlapping sites of connective and soft tissue Primary malignant neoplasm of two or more contiguous sites of connective and soft tissue