Neoplasms (C00-D49)

Note:
Functional activity
All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
Morphology [Histology]
Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
Primary malignant neoplasms overlapping site boundaries
A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
Malignant neoplasm of ectopic tissue
Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes (D37-D48)

Note:
Categories D37-D44, and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made.
Excludes 1:
neoplasms of unspecified behavior (D49.-)
D37 Neoplasm of uncertain behavior of oral cavity and digestive organs [+]
Excludes 1: stromal tumors of uncertain behavior of digestive system (D48.1-)
D38 Neoplasm of uncertain behavior of middle ear and respiratory and intrathoracic organs [+]
Excludes 1: neoplasm of uncertain behavior of heart (D48.7)
D39 Neoplasm of uncertain behavior of female genital organs [+]
D40 Neoplasm of uncertain behavior of male genital organs [+]
D41 Neoplasm of uncertain behavior of urinary organs [+]
D42 Neoplasm of uncertain behavior of meninges [+]
D43 Neoplasm of uncertain behavior of brain and central nervous system [+]
Excludes 1: neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system (D48.2)
D44 Neoplasm of uncertain behavior of endocrine glands [+]
Excludes 1: multiple endocrine adenomatosis (E31.2-)
multiple endocrine neoplasia (E31.2-)
neoplasm of uncertain behavior of endocrine pancreas (D37.8)
neoplasm of uncertain behavior of ovary (D39.1-)
neoplasm of uncertain behavior of testis (D40.1-)
neoplasm of uncertain behavior of thymus (D38.4)
D45 Polycythemia vera
Excludes 1: familial polycythemia (D75.0)
secondary polycythemia (D75.1)
D46 Myelodysplastic syndromes [+]
Use additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
Excludes 2: drug-induced aplastic anemia (D61.1)
D47 Other neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue [+]
D48 Neoplasm of uncertain behavior of other and unspecified sites [+]
Excludes 1: neurofibromatosis (nonmalignant) (Q85.0-)

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