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Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

Excludes 2:: autoimmune disease (systemic) NOS (M35.9)
certain conditions originating in the perinatal period (P00-P96)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
human immunodeficiency virus [HIV] disease (B20)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Other disorders of blood and blood-forming organs (D70-D77)

D70

Neutropenia [+]

Includes:	agranulocytosis decreased absolute neurophile count (ANC)
Code also	, if applicable, mucositis (J34.81, K12.3-, K92.81, N76.81)
Use additional	code for any associated:
Use additional	fever (R50.81)
Excludes 1:	neutropenic splenomegaly (D73.81) transient neonatal neutropenia (P61.5)

D71

Functional disorders of polymorphonuclear neutrophils
Cell membrane receptor complex [CR3] defect
Chronic (childhood) granulomatous disease
Congenital dysphagocytosis
Progressive septic granulomatosis

D72

Other disorders of white blood cells [+]

Excludes 1:

basophilia (D72.824)
immunity disorders (D80-D89)
neutropenia (D70)
preleukemia (syndrome) (D46.9)

D72.0

Genetic anomalies of leukocytes
Alder (granulation) (granulocyte) anomaly
Alder syndrome
Hereditary leukocytic hypersegmentation
Hereditary leukocytic hyposegmentation
Hereditary leukomelanopathy
May-Hegglin (granulation) (granulocyte) anomaly
May-Hegglin syndrome
Pelger-Huët (granulation) (granulocyte) anomaly
Pelger-Huët syndrome

Excludes 1:

Chédiak (-Steinbrinck)-Higashi syndrome (E70.330)

D72.1

Eosinophilia [+]

Excludes 2:

Löffler's syndrome (J82.89)
pulmonary eosinophilia (J82.-)

D72.10

Eosinophilia, unspecified

D72.11

Hypereosinophilic syndrome [HES] [+]

D72.12

Drug rash with eosinophilia and systemic symptoms syndrome
DRESS syndrome

Use additional

code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

D72.18

Eosinophilia in diseases classified elsewhere

Code first

underlying disease, such as:
chronic myelomonocytic leukemia (C93.1-)

D72.19

Other eosinophilia
Familial eosinophilia
Hereditary eosinophilia

D72.8

Other specified disorders of white blood cells [+]

Excludes 1:

leukemia (C91-C95)

D72.81

Decreased white blood cell count [+]

Excludes 1:

neutropenia (D70.-)

D72.82

Elevated white blood cell count [+]

Excludes 1:

eosinophilia (D72.1)

D72.820

Lymphocytosis (symptomatic)
Elevated lymphocytes

D72.821

Monocytosis (symptomatic)

Excludes 1:

infectious mononucleosis (B27.-)

D72.822

Plasmacytosis

D72.823

Leukemoid reaction
Basophilic leukemoid reaction
Leukemoid reaction NOS
Lymphocytic leukemoid reaction
Monocytic leukemoid reaction
Myelocytic leukemoid reaction
Neutrophilic leukemoid reaction

D72.824

Basophilia

D72.825

Bandemia
Bandemia without diagnosis of specific infection

Excludes 1:

confirmed infection - code to infection
leukemia (C91.-, C92.-, C93.-, C94.-, C95.-)

D72.828

Other elevated white blood cell count

D72.829

Elevated white blood cell count, unspecified
Elevated leukocytes, unspecified
Leukocytosis, unspecified

D72.89

Other specified disorders of white blood cells
Abnormality of white blood cells NEC

D72.9

Disorder of white blood cells, unspecified
Abnormal leukocyte differential NOS

D73

Diseases of spleen [+]

D74

Methemoglobinemia [+]

D75

Other and unspecified diseases of blood and blood-forming organs [+]

Excludes 2:

acute lymphadenitis (L04.-)
chronic lymphadenitis (I88.1)
enlarged lymph nodes (R59.-)
hypergammaglobulinemia NOS (D89.2)
lymphadenitis NOS (I88.9)
mesenteric lymphadenitis (acute) (chronic) (I88.0)

D75.0

Familial erythrocytosis
Benign polycythemia
Familial polycythemia

Excludes 1:

hereditary ovalocytosis (D58.1)

D75.1

Secondary polycythemia
Acquired polycythemia
Emotional polycythemia
Erythrocytosis NOS
Hypoxemic polycythemia
Nephrogenous polycythemia
Polycythemia due to erythropoietin
Polycythemia due to fall in plasma volume
Polycythemia due to high altitude
Polycythemia due to stress
Polycythemia NOS
Relative polycythemia

Excludes 1:

polycythemia neonatorum (P61.1)
polycythemia vera (D45)

D75.8

Other specified diseases of blood and blood-forming organs [+]

D75.81

Myelofibrosis
Myelofibrosis NOS
Secondary myelofibrosis NOS

Code first	the underlying disorder, such as: malignant neoplasm of breast (C50.-)
Use additional	code, if applicable, for associated therapy-related myelodysplastic syndrome (D46.-)
Use additional	code for adverse effect, if applicable, to identify drug (T45.1X5)
Excludes 1:	acute myelofibrosis (C94.4-) idiopathic myelofibrosis (D47.1) leukoerythroblastic anemia (D61.82) myelofibrosis with myeloid metaplasia (D47.4) myelophthisic anemia (D61.82) myelophthisis (D61.82) primary myelofibrosis (D47.1)

D75.82

Heparin induced thrombocytopenia (HIT) [+]

Use additional

code, if applicable, for adverse effect of heparin (T45.515-)

D75.83

Thrombocytosis [+]

Excludes 2:

essential thrombocythemia (D47.3)

D75.84

Other platelet-activating anti-PF4 disorders
Spontaneous heparin-induced thrombocytopenia syndrome (without heparin exposure)
Thrombosis with thrombocytopenia syndrome
Vaccine-induced thrombotic thrombocytopenia

Use additional

code, if applicable, for adverse effect of other viral vaccine (T50.B95-)

D75.89

Other specified diseases of blood and blood-forming organs

D75.9

Disease of blood and blood-forming organs, unspecified

D75.A

Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia

Excludes 1:

glucose-6-phosphate dehydrogenase (G6PD) deficiency with anemia (D55.0)

D76

Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue [+]

Excludes 1:

(Abt-) Letterer-Siwe disease (C96.0)
eosinophilic granuloma (C96.6)
Hand-Schüller-Christian disease (C96.5)
histiocytic medullary reticulosis (C96.9)
histiocytic sarcoma (C96.A)
histiocytosis X, multifocal (C96.5)
histiocytosis X, unifocal (C96.6)
Langerhans-cell histiocytosis, multifocal (C96.5)
Langerhans-cell histiocytosis NOS (C96.6)
Langerhans-cell histiocytosis, unifocal (C96.6)
leukemic reticuloendotheliosis (C91.4-)
lipomelanotic reticulosis (I89.8)
malignant histiocytosis (C96.A)
malignant reticulosis (C86.0)
nonlipid reticuloendotheliosis (C96.0)

D77

Other disorders of blood and blood-forming organs in diseases classified elsewhere

Code first	underlying disease, such as: amyloidosis (E85.-) congenital early syphilis (A50.0-) echinococcosis (B67.0-B67.9) malaria (B50.0-B54) schistosomiasis [bilharziasis] (B65.0-B65.9) vitamin C deficiency (E54)
Excludes 1:	rupture of spleen due to Plasmodium vivax malaria (B51.0) splenitis, splenomegaly in late syphilis (A52.79) splenitis, splenomegaly in tuberculosis (A18.85)